Most of the time, powerups are the only help you are going to get in a shmup, but sometimes they seem as a cunning evil plan to destroy you surer than shots: In Darius Gaiden, some last bosses (like Storm Causer) are impossible if you get all the shot powerups, in Souky they increase the rank, in Dodonpachi they almost surely break your chain (this is really, really evil

).
Sometimes you end more afraid of the damn powerups that of the enemies you are supposed to avoid. Or you end crashing in a bullet trying not to get that damn useless weapon. Even in Gradius games, you can lose a preselected shield in the worst possible moment.
So, what are your worst powerup-related nightmares? I'm sure that it is not precisely a minor nag

.