For example, Cotton in low-res mode runs in 448x240.

This is not 4:3 ratio, hence if you run it full screen, it's streched:

But if you lower the horizontal screen size, then it looks proper (notice the black borders):

Here's some closeups of the moon:
Full screen (bad):

Proper shrunken screen (good):

And for kicks, here's Darius on X68K, sadly it's just a demo, game was never finished:
