A streamer spent about 20 minutes with Dezatopia today. Some interesting changes and you can hear some muci.
https://www.twitch.tv/videos/539614599
Entry to the Tower seems to have conditions which change based on the route you're on (get there in less than 15 min, average rank 100 or more are visible here for routes A and B)
Stages don't seem to do world pairing anymore. His stages go from forest to mountain to ocean (and there he loses), where you'd do two of each back to back in Momoiro. There are 5 stages listed on the course select screen - does the tower start at stage 6? Are the routes shorter in Deza?
Rank does go negative. He doesn't get to -99 so not confirmed that it still bottoms out there.
You can uncover shop items in the stages by shooting - doing so slows you down and you lose time, but the tick points from shooting them seems to more than make up for it. These MAY be shot specific (see 6:39 where he shoots a spot with forward and nothing happens, but then something does seem to connect when he uses up shot)
Hitting Givenchy's feet makes the same sounds as the above and shots seem to do more damage there.
Every weapon provides tick score now? IIRC in Momoiro only the front shot did. Shooting may give you more tick score in Deza as well, I'll have to test that. Back shot still doesn't seem to give points on kill though.
Graphical changes: new enemy explosions/boss death death animations, messages now displayed on dying (number of lives left) and respawning/starting a stage (+1 bomb)
With no treasures to collect, money score is much harder to come by - four stages in and he doesn't get any. (Money score being different from money you spend in the shop - seems like the only way to gain money score in Deza will be to max your money at 99,999 and continue to collect gems.)
One of the Ocean stages is different - there's crates floating in the water that aren't there in Momoiro. He dies before we can see much.
There seems to be checkpoints. Which could be bad for milking certain things.